Radiation-Induced Xerostomia

Xerostomia (dry mouth) is a condition in which a person’s salivary glands do not produce enough saliva. Symptoms include difficulty eating, chewing, and speaking, oral pain, sore throat, difficulty sleeping, inability to exercise, uncontrollable dental caries (tooth decay) and inability to wear dentures, yeast infections, and oral burning. Xerostomia has a number of different potential causes but may result from radiation therapy for head and neck cancer or be caused by certain autoimmune diseases such as Sjogren’s Syndrome.. Currently, there is no treatment for people with moderate or severe xerostomia.

We are developing AAV-AQP1 to treat radiation-induced xerostomia (RIX). AAV-AQP1 is an investigational genetic medicine that was designed to increase water conduction in salivary glands that have been damaged by radiation therapy. The genetic medicine introduces a water conducting channel into the damaged glands. We are currently conducting a Phase 2 study for people with moderate or severe dry mouth (xerostomia) caused by radiation therapy for head and neck cancer, the AQUAx2 Study.

MeiraGTx Clinical Trials

MeiraGTx is currently recruiting patients to participate in the following salivary gland gene therapy clinical trials:

Patient Resources

For additional information about xerostomia, please visit the following organizations to find resources and support: