Technician

About MeiraGTx

MeiraGTx is a clinical-stage gene therapy company focused on developing potentially curative treatments for patients living with serious diseases. We currently have six programs in clinical development including three ocular indications, a salivary gland condition, and a Parkinson’s disease program. Our initial focus on diseases of the eye, salivary gland and central nervous system is based on the significant unmet medical need coupled with the high potential gene therapy has to provide meaningful clinical benefit in these areas. With headquarters in New York and London, our global footprint provides us the opportunity to partner with leading institutions around the world, allowing us to deepen our understanding of diseases and their progression.

Our team was built with deep expertise in gene therapy development, allowing us to efficiently advance our programs from preclinical to clinical development. Our core capabilities in viral vector design and optimization and gene therapy manufacturing give us a differentiated approach to developing gene therapies. Additionally, we are developing proprietary technology to potentially enable innovative gene therapy treatments whose expression can be turned on and off with an easily administered small molecule. We believe temporal control of gene therapy products has the potential to transform the gene therapy landscape.

Our state-of-the-art manufacturing facility, completed in early 2018, was designed to meet global regulatory requirements, including the current good manufacturing practices (cGMP) required by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK and the U.S. Food and Drug Administration (FDA). The 29,000-square foot facility has the flexibility and capacity to produce sufficient product for all our clinical trials and will scale to commercial capacity.

We are seeking motivated and enthusiastic technicians to join our growing research and development team.  The applicant should have extensive laboratory experience using standard molecular and cellular biology techniques, will be required to present results and updates at project team meetings, maintain accurate and well-organized experiment records. The qualified candidate will work independently and as part of a team to closely collaborate with other team members.

ROLES AND RESPONSIBILITIES

The Technician is responsible for:

  • Maintain cultures of mammalian cell lines
  • Plasmid DNA extraction and purification, quantification
  • Perform cell-based assays, high throughput screening
  • Analyze, interpret and present experimental results accurately, maintain clear and up-to-date experiment records
  • Collaborate and interact with colleagues, complete assigned duties and lab maintenance jobs
  • Comply with company training and policies

QUALIFICATIONS AND BACKGROUND REQUIREMENTS

Educational Requirements

  • BS in molecular and cellular biology or related field

Desirable skills

  • Hands-on experience in mammalian cell culture and cell-based assay, a plus
  • Experienced in nucleic acid extraction and purification, RT-PCR assay
  • Excellent interpersonal, verbal and written communication skills
  • Self-motivated, energetic, well-organized and able to work in a diverse team environment

Junior Technician

About MeiraGTx

MeiraGTx is a clinical-stage gene therapy company focused on developing potentially curative treatments for patients living with serious diseases. We currently have six programs in clinical development including three ocular indications, a salivary gland condition, and a Parkinson’s disease program. Our initial focus on diseases of the eye, salivary gland and central nervous system is based on the significant unmet medical need coupled with the high potential gene therapy has to provide meaningful clinical benefit in these areas. With headquarters in New York and London, our global footprint provides us the opportunity to partner with leading institutions around the world, allowing us to deepen our understanding of diseases and their progression.

Our team was built with deep expertise in gene therapy development, allowing us to efficiently advance our programs from preclinical to clinical development. Our core capabilities in viral vector design and optimization and gene therapy manufacturing give us a differentiated approach to developing gene therapies. Additionally, we are developing proprietary technology to potentially enable innovative gene therapy treatments whose expression can be turned on and off with an easily administered small molecule. We believe temporal control of gene therapy products has the potential to transform the gene therapy landscape.

Our state-of-the-art manufacturing facility, completed in early 2018, was designed to meet global regulatory requirements, including the current good manufacturing practices (cGMP) required by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK and the U.S. Food and Drug Administration (FDA). The 29,000-square foot facility has the flexibility and capacity to produce sufficient product for all our clinical trials and will scale to commercial capacity.

We are seeking motivated and enthusiastic technicians to join our growing research and development team.  The applicant should have extensive laboratory experience using standard molecular and cellular biology techniques, will be required to present results and updates at project team meetings, maintain accurate and well-organized experiment records. The qualified candidate will work independently and as part of a team to closely collaborate with other team members.

Purpose of Job

The purpose of the job is to provide technical and operational support in the R&D department at MeiraGTx.

Major Activities

  • USP/DSP support with daily activities
  • Tissue culture support
  • Ordering and restocking of laboratory consumables
  • To organise and maintain stocks and deliveries from MeiraGTx’s off site warehouse
  • To maintain the Glassware, autoclaving facilities and weekly/daily calibration of equipment
  • Developing and drafting SOPs/ Work instructions for the unit operations that are being developed

Additional Activities

  • The post-holder will be expected to carry out any other duties that are within the scope, spirit and purpose of the job

Key Performance Indicators

  • Completion of Experiments within provided budget & Timelines

Key Job Competencies

  • Basic understanding of tissue culture techniques
  • Cost Consciousness – works within approved budget; develops and implements cost saving measures; supports ordering of lab reagents and stock checking.
  • Motivation – sets and achieves challenging goals; demonstrates persistence and overcomes obstacles; measures self against standard of excellence.
  • Planning/Organizing – prioritizes and plans work activities; uses time efficiently; plans for additional resources; sets goals and objectives.
  • Professionalism – approaches others in a tactful manner; reacts well under pressure; treats others with respect and consideration regardless of their status or position; accepts responsibility for own actions; follows through on commitments.
  • Oral Communication – speaks clearly and persuasively in positive or negative situations; listens and gets clarification; responds well to questions; demonstrates good presentation skills; participates effectively in meetings.
  • Written Communication – writes clearly and informatively; edits work for spelling and grammar; able to read and interpret written information.
  • Demonstrated commitment to continuous improvement at the individual, department, and organizational levels.

Job Responsibilities

  • Completion of tasks within provided budget & Timelines
  • Support the development of the emerging R&D wet lab facility
  • Assist in the performance of routine maintenance of the Lab
  • Support ordering of consumables and stock checking

Job background

  • A levels or BTech in any Science/ Biological subjects.

Technician

MeiraGTx is seeking an outstanding technician to join our growing research and development team.  The applicant should have extensive laboratory experiences using standard molecular and cellular biology techniques, will be required to present results and updates at project team meetings, maintain accurate and well-organized experiment records. The qualified candidate will work independently and as part of a team to closely collaborate with other team members.

Responsibilities:
  • Maintain cultures of mammalian cell lines
  • Plasmid DNA extraction and purification, quantification.
  • Perform cell-based assays, mammalian cell transfection.
  • Analyze, interpret and present experimental results accurately, maintain clear and up-to-date experiment records.
  • Collaborate and interact with colleagues, complete assigned duties and lab maintenance jobs.
  • Comply with company training and policies.
Qualifications:
  • BS in molecular and cellular biology or related field.
  • Hands-on experience in mammalian cell culture and cell-based assay.
  • Highly experienced in nucleic acid extraction and purification, RT-PCR assay.
  • Excellent interpersonal, verbal and written communication skills
  • Self-motivated, energetic, well-organized and able to work in a diverse team environment.

Senior Scientist

DEPARTMENT: RESEARCH & DEVELOPMENT

Purpose of Job

MeiraGTx is seeking an outstanding and motivated Ph.D. scientist to join our growing research and development team. This senior scientist position requires in-depth scientific knowledge to develop and optimize innovative gene regulation platforms. He or she will be able to design and execute experiments creatively and efficiently, and demonstrate technical leadership. The applicant will be required to present results and updates at project team meetings, maintain accurate and well-organized experiment records. The qualified candidate will work independently and as part of a team to closely collaborate with other team members in developing novel technologies.

Job Responsibilities

  • Design and execute assays to characterize RNA function.
  • Analyze, interpret and present experimental results accurately, maintain clear and up-to-date experiment records.
  • Maintain skills and knowledge in relevant biosciences up to date.
  • Apply new technologies and methods to study design and execution, demonstrate technical leadership, generate laboratory protocols, trouble-shoot and solve issue in experiment.
  • Collaborate and interact with colleagues, complete assigned duties.
  • Comply with company training and policies.

Job Background

  • D. in molecular biology, biochemistry or related field, 4-5 years postdoctoral laboratory experience is preferred.
  • In-depth knowledge and hands-on experience in RNA biology and gene regulation.
  • Strong expertise in RNA structure probing assays.
  • Excellent interpersonal, verbal and written communication skills
  • Self-motivated, energetic and able to work in a diverse team environment.

Associate Scientist

DEPARTMENT: RESEARCH & DEVELOPMENT

Purpose of Job

MeiraGTx is seeking a highly skilled and motivated scientist to join our growing research and development team. The applicant should have extensive laboratory experiences using standard molecular biology techniques, will be required to present results and updates at project team meetings, maintain accurate and well-organized experiment records. The qualified candidate will work independently and as part of a team to closely collaborate with other team members.

Job Responsibilities

  • Maintain cultures of mammalian cell lines
  • Plasmid DNA extraction and purification, quantification.
  • Perform cell-based assays, mammalian cell transfection, viral infection.
  • Analyze, interpret and present experimental results accurately, maintain clear and up-to-date experiment records.
  • Maintain skills and knowledge in relevant biosciences up to date.
  • Collaborate and interact with colleagues, complete assigned duties.
  • Comply with company training and policies.

Job Background

  • Master degree or equivalent with 3+ experience in molecular and cellular biology or related field.
  • Highly experienced in mammalian cell culture and transfection.
  • Highly experienced in molecular biology techniques such as nucleic acid extraction and purification, RT-PCR, molecular cloning.
  • Experience in immunoassays such as ELISA, flow cytometry and Western blot.
  • Highly proficient in designing and executing experiments.
  • Excellent interpersonal, verbal and written communication skills.
  • Self-motivated, energetic, well-organized and able to work in a diverse team environment.