Scott A. Small, M.D.

Dr. Scott A. Small is the Boris and Katz Professor of Neurology at Columbia University, where he is the Director of the Alzheimer’s Disease Research Center. With an expertise in Alzheimer’s disease and cognitive aging, Dr. Small’s research focuses on the hippocampus, a circuit in the brain targeted by these and other disorders, notably schizophrenia. He has pioneered the development and application of high-resolution functional MRI techniques that can pinpoint parts of the hippocampus most affected by aging and disease. His lab then uses this information to try to identify causes of these disorders. Over the years and together with various collaborations, this ‘top-down’ approach has identified novel pathogenic drivers of Alzheimer’s disease, cognitive aging, and schizophrenia. More recently, his lab has used this insight for drug discovery and to develop therapeutic interventions, some of which are currently being tested in clinical trials. Dr. Small has co-authored over 120 articles and his neuroimaging and molecular work has led to numerous patents. Dr. Small is the recipient of numerous awards, including the Beeson Scholar Award in Aging Research from the American Federation on Aging, the McKnight Neuroscience of Brain Disorders Award, the Derek Denny-Brown Young Neurological Scholar Award from the American Neurological Association, and the Lamport Award for Excellence in Clinical Science Research from Columbia University.